Yet, despite this incredible stress, there she was standing on the precipice of history Saturday as she attempted to become the oldest female player of the Open Era to win a Grand Slam event. After winning the French Open past year against Serena Williams, 7-5, 6-4, Muguruza struggled to gain traction and failed to reach the final of a tournament for 12 months.
However, comeback wins over Gilles Muller (quarter-final) and Sam Querrey (semi-final) have shown the first-time Wimbledon finalist has grit in reserves and isn't the type to be bullied off the court.
In an effort to take care of her ever-changing pregnancy bod, Williams has cut back on her daily practice schedule and is hitting the court about twice a week.
Results, however, had largely failed to meet expectations until this year, when she has rediscovered the sort of form to suggest this will not be her last grand slam success.
Highlight of the year was winning the French Open for her first grand slam title.
By the time she faced her final opponent, the statuesque 23-year-old Garbine Muguruza, she had notched up a tally of 87 Wimbledon match-wins, 101 matches altogether, in her 20th Wimbledon appearance-more than her sister on both counts.
"Well, I think I'm here [in the final] because I've done hard work before".
"I just wanna win, no matter who is in front of me", she later said in a TV interview. "So credit to her", Williams said.
Garbine Muguruza has won the first set 7-5 against Venus Williams in the women's final at Wimbledon. "But I want to see if he's that elegant also dancing".
He has won every set he's played in six matches, and while he did not exactly dominate against the 11th-seeded Berdych, Federer was never in much trouble.
The second set was a complete masterclass from the Spaniard, who was putting her previous doubles prowess to good use.
"For me it was a challenge to have her, growing up watching her play". Muguruza had spoken eloquently this week of etching her name onto the Wimbledon honours board alongside Venus, Serena and the other All England Club icons. The last time she appeared in the Wimbledon final was eight years ago when she lost to Serena. "I tried my best to do the things Serena does, but I think there will be other opportunities". She was congratulated by fellow Spaniards Arantxa Sanchez-Vicario and Manuel Santana - legends in their own right - and her victory speech paid tribute to Venus. But because the talent pool has been drained, and the galling dearth of decent American players, it feels like tennis has devolved back into a niche sport, somewhere next to boxing. However, Muguruza dug deep and pulled out the game and the set.
And in her 15-minute post-match press conference Venus said she had not yet spoken to Serena but "she would". "When I'm on the court and I haven't had enough sleep, I just feel sluggish".
The turning point came with Muguruza serving at 4-5 in the opener.
"It's great to go out there and play somebody that you admire", Muguruza said. "Here I am!" said Muguruza after the match.
Williams arrived in England a few weeks after being involved in a two-car accident in Florida. It took me a while actually to calm down, to say, Hey, it's grass, you have to adapt to the surface.
"I was close. I didn't want to lose this time, because I know the difference". I still can't even believe it.