Magdalena Rybarikova v CoCo Vandeweghe (24) - Court 1, second match Slovakian Rybarikova has two advantages going into her first Wimbledon quarter-final on Tuesday - the confidence of having beaten top title contender Karolina Pliskova and the fact that she has defeated Vandeweghe both times the two players have met in a competitive match. Federer's opponent is Milos Raonic - the third time in four years they'll face each other at the tournament.
Djokovic raced to a 3-0 lead and as The Championships doctor came out, spectators reasoned towards a visit to Mannarino, who was seen to be nursing his lower back.
Raonic beat Federer in the semifinals past year, and then lost to Andy Murray in the final.
Novak Djokovic is out of Wimbledon after retiring injured during his quarter-final against Tomas Berdych.
Djokovic needed three set points to finally put the Frenchman away in the first set, though, eventually claiming it 6-2.
The result means Berdych, 31, has reached the semi-finals for the second year running.
Federer said he had learned to manage his body - citing last year's French Open when he arrived at Roland Garros struggling with knee and back injuries and chose to pull out of the tournament before it began.
The victor of the Federer-Berdych match will clash in the final with either Marin Cilic or Sam Querrey, who downed an injured Andy Murray.
Williams, who last won the title at the All England Club in 2008, advanced to the quarterfinals by beating 19-year-old Ana Konjuh 6-3, 6-2.
Cilic and Querrey have played twice before at Wimbledon, with the Croat winning in five sets in 2009 and 2012.
Her much improved fitness showed as she powered through the final set, breaking in the fifth game and ultimately wrapping up the tei 6-7, 7-6, 6-4.
The other member of the Big 4, Rafael Nadal, lost in the fourth round.
But Nadal, Wimbledon victor in 2008 and 2010, is up against a tricky opponent in Luxembourg's left-handed serve and volley specialist Gilles Muller, who beat him in the second round in 2005 - the Spaniard's first loss at the tournament.
Svetlana Kuznetsova became the first player to reach the quarterfinals at Wimbledon.
Five-time Wimbledon victor Williams was handed a Centre Court slot for her tussle with Croatian teenager Ana Konjuh and British home favourite Johanna Konta played France's Caroline Garcia on Court One.
Lewis, however, said bringing forward the start of play "doesn't work for us", citing travelling fans wanting to take advantage of off-peak fares for their journeys. It's just us, the players.
Neil Stubley, the club's head of courts and horticulture, said on Saturday that the measurements his staff had taken over the first week of play showed that the grass was considered to be healthy and within the acceptable standards of use.
Defending champion Andy Murray will open play on Centre Court against Sam Querrey.
The seven-time champion was elated after dispatching big-serving Raonic in just under two hours with 46 winners and only nine unforced errors.