It has taken the Croatian 11 Wimbledon appearances to reach the semi-finals, tied for second most in the Open era with Tommy Haas. However, the shoulder did not allow the Serbs to finish the match against Tomas Berdych.
Djokovic stopped the quarterfinal match during the second set while trailing 7-6 (2), 2-0.
Federer broke Raonic midway in the first set for a 3-2 lead.
Muller equaled his best Grand Slam performance by reaching the quarterfinals.
American tennis player Sam Querrey has cruised into the Wimbledon semi-finals after scoring a stunning five-set upset over Andy Murray. Maybe I could have got the match done in three sets there. Querrey will meet Marin Cilic in a semifinal on Friday.
It's the first time an American man has reached the semifinals at Wimbledon since Andy Roddick in 2009.
American Querrey is no stranger to the big stage and 12 months ago he rose to the occasion by stunning then defending champion Novak Djokovic en route to the quarter-finals.
Both of them are two-time champions at the All England Club, and both of them are now out of the tournament.
The first sensation of the day was when Andy Murray lost against Sam Querrey 3:6, 6:4, 6:7 (4), 6:1, 6:1. Beaten once by his opponent in their previous eight matches, the 30-year-old Scot took an option on a new victory by winning the third set to the forceps. Muller had a marathon match of almost five hours in the previous round against Rafael Nadal, and he saw the court for more than three hours against Cilic.
The two-time Wimbledon champion quickly corrected this gaff by interrupting the reporter and simply saying: "Male player".
It also continues a disappointing year for Murray, whose form has been hampered by a series of physical problems including shingles and flu, as well as injuries to his elbow and, most recently, hip. It happened to Muller in 2005, and it happened to him again on No. 1 Court on Wednesday.
Djokovic was very unhappy at having his fourth-round match delayed until Tuesday and then with the state of Centre Court but comfortably dispatched Adrian Mannarino.