More than 140,000 voters cast their ballots early - an astounding number for a special election, and one that almost matches presidential contests.
Handel served as Georgia's secretary of state from 2007 to 2010, and has centered her campaign on fiscal conservatism and pledging to reduce regulation. She adds, "It's up from the April 18 election which was just under 57,000". In the weeks leading up to election day, Ossoff maintained a slim lead over his Republican opponent Karen Handel, but polls Tuesday morning showed Handel's numbers surging.
Republicans in congressional races for years have made linking Democratic candidates to the House minority leader a major campaign strategy, and Pelosi remains broadly unpopular in Georgia's traditionally Republican-leaning 6th District.
The polls open at 7 a.m. ET and close at 7 p.m. ET.
The most expensive House race in history is about to end with a new member from Georgia. The election will fill a congressional seat that has been held by a Republican since the 1970s.
But Republicans are at risk of losing it in the era of Trump to a 30-year-old Democrat with no legislative experience, Jon Ossoff. (Clinton only lost the Georgia Sixth by 1 point, which is one reason it has become such a nationally watched race.) One strategy may wind up working better than the other, but the actual demographic composition of who turns out for Democrats is basically the same for Ossoff as it was for Clinton.
If Handel were to win, Republicans on Capitol Hill could feel they are on the right track - helping the GOP's push for health care and tax reform legislation.
Ossoff is running in a special election against the Republican candidate Karen Handel to replace Tom Price, who is now the Secretary of Health and Human Services. "VOTE TODAY." Trump's tweets appear to be a last minute effort to get out the vote in the state where the Democrat appears to have a surprising advantage. "KAREN HANDEL FOR CONGRESS", Trump tweeted out in all caps.
"The people of the Sixth District are going to be looking for someone who's been part of this community for almost 25 years", she told reporters after casting her ballot on Tuesday morning, as several dozen nearby Ossoff supporters chanted "Flip the Sixth".
The importance of the race has reportedly helped Democrat John Ossoff compete in a typically Republican stronghold. He has said he grew up in the district and now lives close to Emory University, where his fiancée attends medical school. It's a historically Republican seat that Donald Trump barely won last November, full of the educated suburban voters who populate key swing districts in Florida, California and across the South.
The most expensive House race in US history heads to voters Tuesday in suburban Atlanta. He reported taking in more than $23 million while Handel raised more than $4 million, according to the Federal Election Commission.
That's less than the margin of error and FiveThirtyEight's Nate Silver cautions that "Georgia 6 is a tough district to diagnose".